https://www.nejm.org/doi/full/10.1056/NEJMoa2026116
3.ファイザー製ワクチンの効果、年齢や習慣で差...国立宇都宮病院「高齢者は20代の半分」「喫煙者は35%低下」
https://www.tokyo-np.co.jp/article/124059
4.ファイザービオンテックワクチン接種による総および中和抗体価レベル増加 に関連する因子:喫煙者、高齢者、免疫抑制治療患者で有意に低い
Ref.2 Table 4. Association of Existing Conditions and Covid-19 Severity with SARS-CoV-2 Antibody Levels among Recovered Persons.*
Variable |
No. of Persons |
Log (Pan-Ig Anti-N) (95% CI) |
Pan-Ig Anti–S1-RBD (95% CI) |
IgG Anti-N (95% CI) |
IgM Anti-N (95% CI) |
IgG Anti-S1 (95% CI) |
IgA Anti-S1 (95% CI) |
---|---|---|---|---|---|---|---|
Change in levels per 10 yr of life |
1215 |
0.15 (0.11 to 0.18)† |
0.10 (0.07 to 0.14)† |
0.22 (0.19 to 0.25)† |
0.04 (0.01 to 0.08)‡ |
0.15 (0.09 to 0.20)† |
0.15 (−0.05 to 0.34) |
Female sex |
1215 |
−0.09 (−0.20 to 0.02) |
−0.24 (−0.35 to −0.13)§ |
−0.11 (−0.22 to 0.00) |
−0.04 (−0.15 to 0.07) |
−0.09 (−0.15 to −0.03)‡ |
−0.09 (−0.12 to −0.06)† |
Body-mass index¶ |
542 |
0.03 (0.02 to 0.05)§ |
0.02 (0.00 to 0.03)‡ |
0.02 (0.01 to 0.04)‡ |
0.02 (0.00 to 0.03)‡ |
0.03 (0.01 to 0.06)‡ |
0.03 (0.00 to 0.07) |
Smoker |
1200 |
−0.58 (−0.83 to −0.32)§ |
−0.59 (−0.85 to −0.32)§ |
−0.62 (−0.87 to −0.36)§ |
−0.21 (−0.45 to 0.03) |
−0.58 (−0.82 to −0.34)§ |
−0.58 (−0.84 to −0.32)§ |
Antiinflammation medication¶ |
538 |
−0.36 (−0.61 to −0.12)‡ |
−0.37 (−0.62 to −0.12)‡ |
−0.35 (−0.59 to −0.11)‡ |
−0.02 (−0.23 to 0.20) |
−0.36 (−0.66 to −0.06)‡ |
−0.36 (−0.53 to −0.19)§ |
Hospitalization |
1215 |
−0.09 (−0.20 to 0.02) |
−0.24 (−0.35 to −0.13)§ |
−0.11 (−0.22 to |
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